Female Infertility

If you've been unable to conceive within a reasonable period of time (usually considered 1 year for women below 35 years and 6 months for those above 35 years) seek help from your doctor for evaluation and treatment of infertility. You and your partner should be evaluated. Your doctor will take a detailed medical history and conduct a physical examination.

Fertility tests might include:

Ovulation testing. Serial ultrasounds are done to see the follicular growth in the ovaries. ( Follicular monitoring ) An at-home, over-the-counter ovulation prediction kit detects the surge in luteinizing hormone (LH) that occurs before ovulation. A blood test for progesterone — a hormone produced after ovulation — can also document that you're ovulating. Other hormone levels, such as prolactin, also might be checked.

Ovarian reserve testing. This testing helps determine the quality and quantity of eggs available for ovulation. Women at risk of a depleted egg supply — including women older than 35 — might have this series of blood and imaging tests. Here an AMH ( antimullerian hormone) test is done and ultrasound is done to check the Antral Follicle count.

Other hormone testing. Other hormone tests check levels of ovulatory hormones as well as thyroid and pituitary hormones that control reproductive processes.

Imaging tests. A pelvic ultrasound looks for uterine, ovarian or fallopian tube disease. Sometimes a sonohysterogram, also called a saline infusion sonogram, or a hysteroscopy is used to see details inside the uterus that can't be seen on a regular ultrasound.

Hysterosalpingography. During hysterosalpingography an X-ray contrast is injected into your uterus and an X-ray is taken to check for problems inside the uterus. The test also shows whether the fluid passes out of the uterus and spills out of your fallopian tubes which checks the patency of the tubes . If any problems are found, you'll likely need further evaluation.

Saline salpingography. To check the fallopian tubes with the help of saline and ultrasound.

Depending on your situation, rarely your testing might include:

Laparoscopy. This minimally invasive surgery involves making a small incision beneath your navel and inserting a thin viewing device to examine your fallopian tubes, ovaries and uterus. A laparoscopy can identify endometriosis, scarring, blockages or irregularities of the fallopian tubes, and problems with the ovaries and uterus.

Hysteroscopy: to diagnose and treat uterine problems like polyps, fibroid, septum in uterus

Genetic testing. Genetic testing helps determine whether there any changes to your genes that may be causing infertility.

Treatment

Infertility treatment depends on the cause, your age, how long you've been infertile and personal preferences. Because infertility is a complex disorder, treatment involves significant physical, psychological and time commitments.

Treatments can either attempt to restore fertility through medication or surgery, or help you get pregnant with scientific techniques.

Medications to restore fertility :

Medications that regulate or stimulate ovulation are known as fertility drugs. Fertility drugs are the main treatment for women who are infertile due to ovulation disorders.

Fertility drugs generally work like natural hormones — follicle-stimulating hormone (FSH) and luteinizing hormone (LH) — to trigger ovulation. They're also used in women who ovulate to try to stimulate a better egg or an extra egg or eggs.

Fertility drugs include:

Clomiphene citrate. Taken by mouth, this drug stimulates ovulation by causing the pituitary gland to release more FSH and LH, which stimulate the growth of an ovarian follicle containing an egg. This is generally the first line treatment for women younger than 39 who don't have PCOS.

Gonadotropins. These are in the form of Injection which stimulate the ovary to produce multiple eggs. Gonadotropin medications include human menopausal gonadotropin or hMG and FSH .

Another gonadotropin, human chorionic gonadotropin is used to mature the eggs and trigger their release at the time of ovulation.

Metformin. This drug is used when insulin resistance is a known or suspected cause of infertility, usually in women with a diagnosis of PCOS. Metformin helps improve insulin resistance, which can improve the likelihood of ovulation.

Letrozole. Letrozole belongs to a class of drugs known as aromatase inhibitors and works in a similar fashion to clomiphene. Letrozole is usually used for woman younger than 39 who have PCOS.

Bromocriptine. Bromocriptine , a dopamine agonist, might be used when ovulation problems are caused by excess production of prolactin (hyperprolactinemia) by the pituitary gland.